Comparison of methods for DE-CMR infarct size quantification - reproducibility among three core labs
نویسندگان
چکیده
Background Infarct size measurements with delayed-enhancement cardiovascular magnetic resonance (DE-CMR) are being used as surrogate endpoints in acute myocardial infarction (AMI) trials comparing therapeutic strategies. Semiautomated techniques using signal intensity thresholding are thought to be more reproducible than manual planimetry to define AMI borders. For both methods, endo-/ epicardial borders are determined by manual planimetry, which was not considered in prior reproducibility studies. Visual scoring of AMI size based on a standard 17-segment, 5-point score is faster and does not require planimetry of endo-/epicardial borders. We compared the reproducibility of visual scoring, manual planimetry and semiautomated techniques.
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Sources of variability in quantification of cardiovascular magnetic resonance infarct size - reproducibility among three core laboratories
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